Send your peptide name, sample count, and the tests you need. We return a fixed-price quote, usually within one business day.
Bacterial endotoxins are lipopolysaccharides (LPS) shed from gram-negative bacteria cell walls. They're heat-stable, meaning standard sterilization doesn't eliminate them. Even trace amounts can trigger dangerous pyrogenic responses in humans. For any peptide intended for injection, cell culture, or pharmaceutical compounding, endotoxin testing isn't optional, it's a safety requirement.
Kinetic chromogenic LAL method using Charles River Endosafe nexgen-PTS. Quantitative results with 0.01 EU/mL sensitivity: the most accurate method available.
Testing performed per USP <85> Bacterial Endotoxins Test guidelines. Results reported against all applicable limits for injectable, intrathecal, and research applications.
Combine endotoxin testing with heavy metal screening (ICP-MS) and residual solvent analysis (GC-MS) for a complete contaminant safety profile.
| Application | USP Limit | Standard |
|---|---|---|
| Injectable peptides | < 5 EU/kg body weight | USP <85> |
| Intrathecal use | < 0.2 EU/kg body weight | USP <85> |
| Cell culture research | < 0.5 EU/mL | Recommended |
| General research use | < 20 EU/mL | Typical spec |
FDA requires endotoxin testing for sterile compounded preparations. Our LAL testing provides USP-compliant documentation for pharmacy board inspections and 503B outsourcing facility requirements.
Endotoxin contamination confounds cell-based assays, activates TLR4 signaling, and can invalidate in vivo study results. Verify your peptides are endotoxin-free before experiments.
Provide endotoxin-free certificates to your customers. Independent LAL testing builds trust and differentiates your products from competitors who lack safety documentation.
IND-enabling studies require endotoxin testing per FDA guidelines. Our quantitative LAL results meet regulatory submission requirements for investigational peptide products.
LAL assay per USP <85> with 0.01 EU/mL sensitivity, 9-11 business day turnaround, nationwide service.