MOTS-c Testing Services
MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the 12S rRNA gene of mitochondrial DNA. It is a 16-amino acid peptide that has gained significant research interest for its role in metabolic regulation, exercise mimetic effects, and longevity.
Research Applications
Common research areas for MOTS-c
- Metabolic disease research
- Exercise physiology studies
- Aging and longevity research
- Insulin resistance investigations
- Mitochondrial biology studies
Peptide Information
Molecular details and sample requirements
Sequence / Structure:
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular Weight
2174.56 g/mol
Formula
C101H152N28O22S2
Recommended Purity
≥95%
Sample Size
1-2 mg lyophilized
Our MOTS-c Testing Services
Comprehensive analytical testing to ensure MOTS-c quality and purity
Purity Testing
HPLC analysis to verify MOTS-c purity levels
Identity Verification
Mass spectrometry to confirm molecular identity
Third-Party Verification
Independent COA verification for MOTS-c
Certificate of Analysis
Official US laboratory documentation
Ready to test your peptides?
Send your peptide name, sample count, and the tests you need. We return a fixed-price quote, usually within one business day.
- validated analytical methods, independent of any supplier
- 9-11 business day standard turnaround
- Traceable COA with chromatograms and method parameters
MOTS-c Testing Methodology
Our analytical workflow for MOTS-c follows USP <1225> guidance for validated chromatographic methods. Each lot is processed by a credentialed analyst with documented chain of custody.
Step 1
Sample intake & chain of custody
Your MOTS-c sample (1-2 mg lyophilized) is logged at our Florida lab with a unique ID, photographed, and stored at -20 °C until analysis.
Step 2
Reverse-phase HPLC purity
MOTS-c is dissolved in mobile phase and run on a C18 column with a water/acetonitrile gradient containing 0.1% TFA. UV detection at 214 nm quantifies the main peak and any related impurities.
Step 3
LC-MS identity confirmation
An aliquot is analyzed by liquid chromatography-mass spectrometry. The observed monoisotopic mass is compared against the theoretical molecular weight (2174.56 g/mol) for MOTS-c to confirm identity.
Step 4
Impurity profiling & reporting
Related substances, truncations, and oxidation products are quantified. Findings are compiled into a signed Certificate of Analysis with chromatograms, mass spectra, and analyst interpretation.
MOTS-c Purity Notes
Recommended research-grade purity for MOTS-c is ≥95%. Lot-to-lot variation is common with solid-phase synthesis, so independent verification matters.
Common impurities to watch
- Truncated sequences from incomplete coupling
- Deletion peptides missing one or more residues
- Oxidation of methionine, tryptophan, or cysteine
- Residual TFA, acetate, or solvent counter-ions
- Aggregates and dimers from improper storage
What our COA confirms
- Main peak purity by HPLC area %
- Observed vs theoretical mass (2174.56 g/mol)
- Named impurities ≥ 0.1% area
- Net peptide content where applicable
- Method, column, and instrument metadata
MOTS-c Handling, Storage & Safety
Guidance below is for laboratory and research personnel only. MOTS-c is supplied for research use and is not intended for human or veterinary use.
Storage
Store lyophilized MOTS-c at -20 °C, protected from light and moisture. After reconstitution, aliquot and store at -80 °C; avoid repeated freeze-thaw cycles.
Reconstitution
Reconstitute in bacteriostatic or sterile water in a clean environment. Allow vials to reach room temperature before opening to prevent moisture condensation on the powder.
PPE & shipping
Handle with gloves, lab coat, and eye protection. Ship samples to ACS overnight on dry ice or cold packs in a rigid, leak-proof container with a packing slip referencing your quote.
This page is informational and does not constitute medical advice. Consult your institution's safety officer and SDS before working with MOTS-c.
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