About this category
Growth hormone secretagogues are short peptides that are sensitive to deamidation and oxidation. Lots that pass a basic HPLC peak count can still hide acetate counterion variation, oxidized tryptophan, or wrong stereoisomers. We run RP-HPLC purity, LC-MS/MS for identity, and confirm acetate content where applicable.
Featured peptides we test
Sermorelin
3357.88 g/mol
Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of the first 29 amino acids of the native GHRH molecule. It stimulates the natural production and release of growth hormone.
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Ipamorelin
711.86 g/mol
Ipamorelin is a synthetic pentapeptide that acts as a selective growth hormone secretagogue. It stimulates the release of growth hormone without affecting cortisol or prolactin levels.
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Tesamorelin
5135.89 g/mol
Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of 44 amino acids with a trans-3-hexenoic acid modification. It is FDA-approved for reducing visceral adipose tissue and is widely studied in metabolic and body composition research.
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Hexarelin
887.04 g/mol
Hexarelin is a synthetic hexapeptide and one of the most potent growth hormone secretagogues. It also has potential cardioprotective effects independent of GH release.
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GHRP-2
817.97 g/mol
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide that stimulates growth hormone release. It is one of the most potent GH secretagogues and also stimulates appetite.
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GHRP-6
872.97 g/mol
GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide that stimulates growth hormone secretion and has strong appetite-stimulating effects through ghrelin receptor activation.
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CJC-1295 (no DAC) / Modified GRF 1-29
3367.93 g/mol
CJC-1295 without DAC (also called Modified GRF 1-29) is a GHRH analog with a much shorter half-life than the DAC version. It produces pulsatile GH release more closely matching natural physiology and is often paired with a GHRP.
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Sample submission
- Most GH secretagogues need only 0.5 mg for HPLC + MS.
- CJC-1295 (DAC vs no-DAC) requires explicit identification on the submission form.
- Tesamorelin/Ipamorelin blends are tested as separate components.
Common impurities
- Oxidized Trp / Met residues
- Deamidated Asn / Gln
- Acetate counterion variation
- Truncated 1-2 residue deletions
Recommended tests
- RP-HPLC Purity
- LC-MS Identity
- Acetate Content
- Endotoxin (LAL)
All GH Secretagogues peptides we test (9)
GH Secretagogues Testing Methodology
Our analytical workflow for gh secretagogues peptides follows USP <1225> guidance for validated chromatographic methods. Every lot is processed by a credentialed analyst with documented chain of custody.
Step 1
Sample intake & cold storage
Each GH Secretagogues sample is logged with a chain-of-custody ID and stored at -20 °C upon arrival at our Florida lab.
Step 2
Reverse-phase HPLC purity
Samples are run on a C18 column using a water/acetonitrile gradient with 0.1% TFA, with UV detection at 214 nm to quantify main peak purity and named impurities.
Step 3
LC-MS / Orbitrap identity
Observed monoisotopic mass is compared against the theoretical mass for each gh secretagogues compound to confirm identity. Blends are deconvoluted to quantify each active component.
Step 4
Optional residual & endotoxin testing
Residual solvents (GC-MS), residual TFA / acetate counterions, and bacterial endotoxin (LAL) are run on request based on intended downstream use.
Step 5
Signed Certificate of Analysis
Findings are compiled into a signed COA with chromatograms, spectra, instrument metadata, and analyst interpretation, delivered within 9-11 business days.
GH Secretagogues Purity Notes
Recommended research-grade purity for gh secretagogues peptides is typically ≥ 98% by HPLC area. Synthesis-related impurities are common and only show up under proper analytical scrutiny.
Common impurities to watch
- Oxidized Trp / Met residues
- Deamidated Asn / Gln
- Acetate counterion variation
- Truncated 1-2 residue deletions
What our COA confirms
- Main peak purity by HPLC area %
- Observed vs theoretical monoisotopic mass
- Named impurities ≥ 0.1% area
- Net peptide content where applicable
- Method, column, and instrument metadata
GH Secretagogues Handling, Storage & Safety
Guidance below is for laboratory and research personnel only. GH Secretagogues peptides are supplied for research use and are not intended for human or veterinary use.
Storage
Store lyophilized material at -20 °C, protected from light and moisture. After reconstitution, aliquot and store at -80 °C; avoid repeated freeze-thaw cycles.
Reconstitution
Reconstitute in bacteriostatic or sterile water in a clean environment. Allow vials to reach room temperature before opening to prevent moisture condensation on the powder.
PPE & shipping
Handle with gloves, lab coat, and eye protection. Ship samples to ACS overnight on dry ice or cold packs in a rigid, leak-proof container with a packing slip referencing your quote.
This page is informational and does not constitute medical advice. Consult your institution's safety officer and SDS before working with these compounds.
Frequently asked questions
Related testing resources
- HPLC purity testing for gh secretagogues peptides
- Mass spectrometry identity confirmation (ESI-MS)
- Heavy metal and residual solvent screening
- LAL endotoxin testing for injectable peptides
- Peptide testing cost by assay
- How to ship peptides to our lab
- Independent third-party COA verification
- Peptide testing labs near me — all 50 states
- How to read a peptide Certificate of Analysis
- What peptide testing labs measure
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Compounded Peptide Blend Testing
Component-level analysis of compounded peptide blends such as Tesamorelin/Ipamorelin and Retatrutide/Cagrilintide.