About this category
This category mixes peptides (MOTS-c, SS-31, Humanin) with small molecules (NAD+, BAM15, SLU-PP-332, 5-Amino-1MQ). Each requires the right analytical approach. NAD+ degrades quickly and needs cold-chain handling. We use HPLC-UV, LC-MS, and stability-indicating methods as appropriate.
Featured peptides we test
NAD+ (Nicotinamide Adenine Dinucleotide)
663.43 g/mol
NAD+ is a critical coenzyme found in every cell of the body, essential for cellular energy metabolism, DNA repair, and sirtuin activation. It has become one of the most popular compounds in longevity and anti-aging research, often administered as an injectable or IV infusion.
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MOTS-c
2174.56 g/mol
MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the 12S rRNA gene of mitochondrial DNA. It is a 16-amino acid peptide that has gained significant research interest for its role in metabolic regulation, exercise mimetic effects, and longevity.
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SS-31 (Elamipretide)
640.77 g/mol
SS-31 (Elamipretide, also known as Bendavia or MTP-131) is a mitochondria-targeted tetrapeptide that selectively concentrates in the inner mitochondrial membrane. It interacts with cardiolipin and has shown remarkable potential in protecting mitochondrial function, reducing oxidative stress, and improving cellular energy production in preclinical and clinical research.
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Humanin
2687.27 g/mol
Humanin is a 24-amino acid mitochondrial-derived peptide encoded within the 16S rRNA gene of mitochondrial DNA. It is studied for its cytoprotective, neuroprotective, and metabolic effects, and its decline with age makes it a focus of longevity research.
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5-Amino-1MQ
173.21 g/mol
5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular energy metabolism. By blocking NNMT, it may promote fat cell metabolism and has become popular in metabolic and body composition research.
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BAM15
400.31 g/mol
BAM15 is a mitochondrial protonophore uncoupler studied for obesity and metabolic disease. Unlike DNP, it has shown a wider therapeutic window in preclinical models.
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SLU-PP-332
~430 g/mol
SLU-PP-332 is a small-molecule pan-agonist of estrogen-related receptors (ERRα, β, γ) studied as an exercise mimetic. Preclinical research has shown effects on endurance, metabolism, and body composition.
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Sample submission
- NAD+ samples must ship overnight on dry ice.
- Small molecules use HPLC-UV; peptides use HPLC + MS.
- BAM15 + SLU-PP-332 stacks are quantified per component.
Common impurities
- NAD+ degradation products (nicotinamide, ADP-ribose)
- Oxidation
- Process impurities
Recommended tests
- HPLC Purity
- LC-MS Identity
- Stability Profile
All Mitochondrial / Longevity peptides we test (9)
Mitochondrial / Longevity Testing Methodology
Our analytical workflow for mitochondrial / longevity peptides follows USP <1225> guidance for validated chromatographic methods. Every lot is processed by a credentialed analyst with documented chain of custody.
Step 1
Sample intake & cold storage
Each Mitochondrial / Longevity sample is logged with a chain-of-custody ID and stored at -20 °C upon arrival at our Florida lab.
Step 2
Reverse-phase HPLC purity
Samples are run on a C18 column using a water/acetonitrile gradient with 0.1% TFA, with UV detection at 214 nm to quantify main peak purity and named impurities.
Step 3
LC-MS / Orbitrap identity
Observed monoisotopic mass is compared against the theoretical mass for each mitochondrial / longevity compound to confirm identity. Blends are deconvoluted to quantify each active component.
Step 4
Optional residual & endotoxin testing
Residual solvents (GC-MS), residual TFA / acetate counterions, and bacterial endotoxin (LAL) are run on request based on intended downstream use.
Step 5
Signed Certificate of Analysis
Findings are compiled into a signed COA with chromatograms, spectra, instrument metadata, and analyst interpretation, delivered within 9-11 business days.
Mitochondrial / Longevity Purity Notes
Recommended research-grade purity for mitochondrial / longevity peptides is typically ≥ 98% by HPLC area. Synthesis-related impurities are common and only show up under proper analytical scrutiny.
Common impurities to watch
- NAD+ degradation products (nicotinamide, ADP-ribose)
- Oxidation
- Process impurities
What our COA confirms
- Main peak purity by HPLC area %
- Observed vs theoretical monoisotopic mass
- Named impurities ≥ 0.1% area
- Net peptide content where applicable
- Method, column, and instrument metadata
Mitochondrial / Longevity Handling, Storage & Safety
Guidance below is for laboratory and research personnel only. Mitochondrial / Longevity peptides are supplied for research use and are not intended for human or veterinary use.
Storage
Store lyophilized material at -20 °C, protected from light and moisture. After reconstitution, aliquot and store at -80 °C; avoid repeated freeze-thaw cycles.
Reconstitution
Reconstitute in bacteriostatic or sterile water in a clean environment. Allow vials to reach room temperature before opening to prevent moisture condensation on the powder.
PPE & shipping
Handle with gloves, lab coat, and eye protection. Ship samples to ACS overnight on dry ice or cold packs in a rigid, leak-proof container with a packing slip referencing your quote.
This page is informational and does not constitute medical advice. Consult your institution's safety officer and SDS before working with these compounds.
Frequently asked questions
Related testing resources
- HPLC purity testing for mitochondrial / longevity peptides
- Mass spectrometry identity confirmation (ESI-MS)
- Heavy metal and residual solvent screening
- LAL endotoxin testing for injectable peptides
- Peptide testing cost by assay
- How to ship peptides to our lab
- Independent third-party COA verification
- Peptide testing labs near me — all 50 states
- How to read a peptide Certificate of Analysis
- What peptide testing labs measure
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